Grimaldo was part of the build-up to the goal after he gave a back-heel pass to Frimpong.
Earlier, Boniface was denied a goal in the 21st minute when the Video Assistant Referee caught Frimpong in an offside position.
Tammy Abraham’s appeal for a penalty was turned down as the referee waved play on.
Reijnders registered a superb attempt at goal but Leverkusen’s goalie Hradecky made a brilliant save to savour his team’s lead.
The home side has won its two games in the tournament after it earned a 4-0 win against Feyenoord.
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