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Researchers at the University of Dundee have revealed in the greatest detail yet the workings of molecules called protein degraders which can be deployed to combat what have previously been regarded as "undruggable" diseases, including cancers and neurodegenerative diseases.

Protein degrader molecules are heralding a revolution in drug discovery, with more than 50 drugs of this type currently being tested in clinical trials for patients with diseases for which no other options exist.

The Centre for Targeted Protein Degradation (CeTPD) at the University of Dundee is one of the world's leading centers for research into how protein degraders work and how they can most effectively be put to use for a new generation of drugs.

Now researchers have revealed previously invisible levels of detail and understanding of how the protein degraders work, which in turn is allowing for even more targeted use of them at the molecular level.

Ph.D. student Charlotte Crowe, together with Dr. Mark Nakasone, Senior Postdoctoral Scientist at CeTPD, used a technique called cryo-electron microscopy (cryo-EM), which enables scientists to see how biomolecules move and interact with each other.

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