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The San Francisco 49ers opened the season with a double-digit win over the Jets, but they have fallen on hard times since. They lost back-to-back road games against the Vikings and Rams a suffered multiple key injuries. Running backs Christian McCaffrey (Achilles) and Elijah Mitchell (hamstring) will both miss Sunday’s game against the Patriots during the Week 4 NFL schedule, while wide receiver Deebo Samuel (calf) could also sit. San Francisco is still a 10.5-point favorite in the Week 4 NFL odds against the Patriots. New England has already pulled off one big upset this season, taking down Cincinnati as an 8.5-point road underdog in Week 1.

The Patriots are coming off a 24-3 loss to the Jets, so should you fade them with your Week 4 NFL picks and NFL score predictions? So before you make any Week 4 NFL picks, you need to see the NFL against the spread, over-under, and money line predictions powered by the self-learning SportsLine AI.

Built using cutting-edge artificial intelligence and machine learning techniques by SportsLine’s Data Science team, AI Predictions and AI Ratings are generated for each game. The AI predictions are determined by statistically learning from each team’s historical data and then quantitatively evaluating the strength of the opponent’s defense by assigning a numeric value out of 100 called a matchup score.

Once a prediction is formulated, the AI rating is generated using the prediction, the matchup score, and the odds of the market. For example, you could see an A-rating on an over bet if a team is facing a poor defense, their prediction differs from the line and there are favorable odds.

In addition, SportsLine AI is the first fully automated predictive model at SportsLine. It continuously refreshes on the most recent available data and can help you spot the biggest discrepancies in the lines. Last season, SportsLine’s AI PickBot hit a whopping 1,674 4.5- and 5-star prop picks. Anyone who has followed it is way up.

For Week 4 NFL betting, the AI PickBot has evaluated the NFL odds and provided NFL betting predictions for all 16 games. You can only see the AI predictions for the Week 4 NFL schedule here.

Top Week 4 NFL AI picks

After analyzing every game in Week 4, the AI PickBot says the Jaguars cover as 6.5-point road underdogs against the Texans. While Jacksonville is winless through its first three games of the season, Houston has not proven itself to be a reliable favorite. The Texans won their first two games by less than a touchdown before getting blown out by Minnesota in a 34-7 final last week.

The Texans opened as 3.5-point home favorites for this matchup, so the current line offers a chance for bettors to snag a larger number on the underdog. The Texans were without running back Joe Mixon (ankle) last week, and they averaged just 2.7 rushing yards per attempt. He could return this week, but his lingering injury is another reason why the AI PickBot has Jacksonville staying within a field goal on Sunday. See its other Week 4 football predictions and football picks at SportsLine.

How to make Week 4 NFL picks

In addition, the AI PickBot has generated 11 other A-rated picks for Week 4. You need to see the AI PickBot’s picks before making any Week 4 NFL bets of your own. You can only see them at SportsLine.

Who wins and covers each Week 4 NFL game, and which A-rated picks should you target? Visit SportsLine now to see the top NFL picks against the spread, over-under, and on money line, all from the brand-new SportsLine AI PickBot that nailed 1,674 top-rated picks last season.

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