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The Texans have already opened up a two-game lead in the AFC South standings after wins against the Colts and Bears while the rest of the division is winless. On Sunday, they’ll look to continue that dominance when they visit the Vikings (+2.5). The Vikings are coming off a shocking win over the 49ers as home underdogs last week and Sam Darnold’s squad is also unbeaten entering Week 3. It’ll be a showdown to consider for anyone making NFL score predictions and NFL picks this week.

The other battle between unbeatens on the Week 3 NFL schedule is Steelers (+0.5) vs. Chargers, with both teams also exceeding early expectations. Which teams should you back in those matchups and how can you dial in your Week 3 NFL predictions? Before you make any Week 3 NFL picks, you need to see the NFL against the spread, over-under, and money line predictions powered by SportsLine AI.

Built using cutting-edge artificial intelligence and machine learning techniques by SportsLine’s Data Science team, AI Predictions and AI Ratings are generated for each game. The AI predictions are determined by statistically learning from each team’s historical data and then quantitatively evaluating the strength of the opponent’s defense by assigning a numeric value out of 100 called a matchup score.

Once a prediction is formulated, the AI rating is generated using the prediction, the matchup score, and the odds of the market. For example, you could see an A-rating on an over bet if a team is facing a poor defense, their prediction differs from the line and there are favorable odds.

In addition, SportsLine AI is the first fully automated predictive model at SportsLine. It continuously refreshes on the most recent available data and can help you spot the biggest discrepancies in the lines. Last season, SportsLine’s AI PickBot hit a whopping 1,674 4.5- and 5-star prop picks. Anyone who has followed it is way up.

For Week 3, the AI PickBot has evaluated the NFL odds and provided NFL betting predictions for all 16 games. You can only see the AI predictions for the Week 3 NFL schedule here.

Top Week 3 NFL AI picks

After analyzing every game in Week 3, the AI PickBot says the Rams cover as 7.5-point home underdogs against the 49ers. The Rams lost their opener in overtime on the road against the Lions and are coming off a 41-10 throttling at the hands of the Cardinals in Arizona. To make matters worse, they’ll be without Puka Nacua (shoulder), Cooper Kupp (ankle) and multiple offensive lineman on Sunday.

However, they will be making their home debut and they’ve had success in the underdog spot recently against the 49ers. Los Angeles won outright as 5.5-point road underdogs in San Francisco late last season and also covered as 7.5-point home underdogs earlier in the season. The 49ers are also banged up and will be without Christian McCaffrey (calf) and Deebo Samuel (calf) on Sunday, which is a big reason why the AI PickBot grades the Rams covering as an A-rated pick. See its other Week 3 football predictions and football picks at SportsLine.

How to make Week 3 NFL picks

In addition, the AI PickBot has generated five other A-rated picks for Week 3. You need to see the AI PickBot’s picks before making any Week 3 NFL bets of your own. You can only see them at SportsLine.

Who wins and covers each Week 3 NFL game, and which A-rated picks should you target? Visit SportsLine now to see the top NFL picks against the spread, over-under, and on money line, all from the brand-new SportsLine AI PickBot that nailed 1,674 top-rated picks last season.

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