The Week 1 NFL schedule is loaded with marquee NFL matchups, and one of the biggest is Cowboys vs. Browns. Both teams made the postseason last year but suffered early exits, with Dallas losing 48-32 against the Packers and Cleveland losing 45-14 against the Texans. Now,, they’ll have the opportunity to prove that they’ve mentally recovered against another team with title aspirations to open the 2024 season. The latest Week 1 NFL odds list the Browns as 2.5-point favorites at home, one of nine games on the schedule with NFL spreads of a field goal or less.

Which teams should you back in all of those games and what should your Week 1 NFL score predictions look like? Before you make any Week 1 NFL picks, you need to see the NFL against the spread, over-under, and money line predictions powered by SportsLine AI.

Built using cutting-edge artificial intelligence and machine learning techniques by SportsLine’s Data Science team, AI Predictions and AI Ratings are generated for each game. The AI predictions are determined by statistically learning from each team’s historical data and then quantitatively evaluating the strength of the opponent’s defense by assigning a numeric value out of 100 called a matchup score.

Once a prediction is formulated, the AI rating is generated using the prediction, the matchup score, and the odds of the market. For example, you could see an A-rating on an over bet if a team is facing a poor defense, their prediction differs from the line and there are favorable odds.

In addition, SportsLine AI is the first fully automated predictive model at SportsLine. It continuously refreshes on the most recent available data and can help you spot the biggest discrepancies in the lines. Last season, SportsLine’s AI PickBot hit a whopping 1,674 4.5- and 5-star prop picks. Anyone who has followed it is way up.

For Week 1, the AI PickBot has evaluated the NFL odds and provided NFL predictions for all 16 games. You can only see the AI predictions for the Week 1 NFL schedule here.

Top Week 1 NFL AI picks

After analyzing every game in Week 1, the AI PickBot says the Broncos cover as six-point underdogs against the Seahawks in a game that has earned an A-rated pick. Both of these teams got themselves into playoff contention during the middle portion of the 2023 season but both fell short, with the Broncos finishing at 8-9 and the Seahawks going 9-8.

However, Denver’s season was a three-win improvement over the year prior and it appeared that Sean Payton had his team buying in during the middle of the season, ripping off five consecutive wins after a 1-5 start. Meanwhile, Seattle saw its point differential fall for a third consecutive season, with the Seahawks outscored by 38 points on the year despite a winning record. Ultimately, the AI PickBot sees this game much closer than the oddsmakers do, predicting a 21.86-20.34 final on average. See its other Week 1 football predictions and football picks at SportsLine.

How to make Week 1 NFL picks

In addition, the AI PickBot has generated eight more A-rated picks for Week 1. You need to see the AI PickBot’s analysis before making any Week 1 NFL bets. You can only see it at SportsLine.

Who wins and covers each Week 1 NFL game, and which A-rated picks should you be targeting? Visit SportsLine now to see the top NFL picks against the spread, over-under, and on money line, all from the brand-new SportsLine AI PickBot that nailed 1,674 top-rated picks last season.

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