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A group led by Prof. Horacio Cabral has discovered a new method to construct protein complex-based therapeutics.

Prof. Cabral is a visiting scientist from the Innovation Center for NanoMedicine (iCONM), and is Associate Professor of the Department of Bioengineering, Graduate School of Engineering, University of Tokyo.

The paper, titled "Nano-enabled IL-15 superagonist via conditionally stabilized protein-protein interactions eradicates solid tumors by precise immunomodulation," was published in the Journal of the American Chemical Society on October 2, 2024.

Protein complexes are critical regulators of diverse biological processes, exhibiting unique functions that make them promising candidates for therapeutic applications. For example, interlukin-15 (IL-15) can bind with its receptor α domain (IL-15Rα) to form a superagonistic complex, which can effectively activate antitumoral immunity by facilitating the trans-presentation of IL-15 to immune cells.

However, protein complexes are mainly formed by dynamic non-covalent interactions, leading to instability and transient effective time in biological environments. Thus, delivery strategies are needed to mediate stable delivery of protein complexes.

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