Presented at UEG Week 2024, the study focuses on an enzyme called Sterol O-acyltransferase 2 (SOAT2), which plays a critical role in fat absorption in the small intestine. By inhibiting this enzyme in the small intestine, the study offers a promising therapeutic approach to reduce fat absorption and potentially prevent obesity.
Despite extensive research into fat metabolism, effective inhibitors of intestinal fatty acid uptake have until now remained elusive. "For years, researchers have studied fat metabolism, but finding an effective way to block fat absorption has been difficult," explained lead researcher Dr. Wentao Shao. "While most strategies focus on reducing dietary fat intake, our approach targets the body's fat absorption process directly."
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