The world champions are without veteran lock Eben Etzebeth, while there is a welcome return for Jasper Wiese at No 8.
Sacha Feinberg-Mngomezulu and Aphelele Fassi are retained at No 10 and No 15, respectively.
For more news on the Springboks, visit our dedicated section.
Springbok coach Rassie Erasmus has made several changes to his team for Saturday's Rugby Championship encounter against the All Blacks at Ellis Park.
In all, there are nine changes to the team that beat the Wallabies 30-12 in Perth.
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