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However, the effectiveness of these therapies hinges on the internal structure of the LNPs, which can significantly impact their ability to deliver siRNA. Traditional methods often fall short in providing the detailed molecular insights needed to fine-tune LNP design for optimal therapeutic efficacy.

A study published in the Journal of Controlled Release on August 2, 2024, led by Assistant Professor Keisuke Ueda from the Graduate School of Pharmaceutical Sciences, Chiba University, introduces a novel approach to improving siRNA-loaded LNPs.

By employing NMR-based molecular-level characterization, the research investigates how different siRNA mixing methods affect the uniformity and molecular state of siRNA within LNPs.

The research was coauthored by Dr. Hidetaka Akita from the Graduate School of Pharmaceutical Sciences, Tohoku University; Dr. Kenjirou Higashi from the Graduate School of Pharmaceutical Sciences, Chiba University; and Dr. Kunikazu Moribe (last author) from the Graduate School of Pharmaceutical Sciences, Chiba University.

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