The 28-year-old's injury is a significant setback for City's Premier League and Champions League ambitions.
Rodri has been a key player for City, with his performances earning him consideration for the Ballon d'Or this year.
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Manchester City and Spain midfielder Rodri could miss the rest of the season due to an anterior cruciate ligament injury, according to reports in Spain on Monday.
The 28-year-old limped off during City's 2-2 draw against Arsenal in the Premier League on Sunday after going down holding his right knee.
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