United, despite being favourites, are expected to face a stern test from a Porto side with a rich history in European competitions.
With both teams eyeing progression to the knockout stages, this encounter promises to be a high-stakes affair.
Meanwhile, Tottenham Hotspur will travel to Hungary to take on Ferencvaros.
Spurs are favourites in this matchup and are expected to continue their strong form under their manager, with hopes of securing a vital away win to keep their Europa League campaign on track.
In Italy, Lazio will face a tough test as they host French side Nice.
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