The London-based club, entering the match as strong favourites, are keen to continue their march towards the knockout stages with a commanding home performance.
Italian giants Fiorentina are also in action at 20:00 GMT, hosting Welsh side TNS. Fiorentina, who have shown strong form in recent weeks, are expected to secure a comfortable win in front of their home fans.
Earlier in the day, Spanish side, Real Betis, will travel to Poland to face Legia Warszawa at 17:45 GMT.
Betis, coming in as favourites, will look to build on their recent European outings and secure vital points on the road.
Elsewhere, Panathinaikos will take on Borac Banja Luka, and Danish club FC Copenhagen will host Jagiellonia Bialystok, with both matches set for 20:00 GMT.
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