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Researchers have found that cellular droplets function in more diverse ways than previously known. The ability to fission membranes in cells was previously attributed solely to certain proteins. In a new publication in Nature, an international research team now shows that small cellular droplets, so-called biomolecular condensates, can also split membranes without the help of proteins.

Simulations by mathematician Prof Sebastian Aland of the TU Bergakademie Freiberg illustrate how the droplets exert capillary forces on membranes. These forces bend the membrane, whereby the droplet is trapped and ultimately split off. The findings could open up new possibilities for medical treatments in the future, as biomolecular condensates are associated with the development of diseases such as Alzheimer's or cancer.

"Because the existence of biomolecular condensates has only been known for a good decade, we still know little about how they work," says Professor Sebastian Aland from TU Bergakademie Freiberg. In contrast to other cellular components, such as classic organelles, condensates do not have a membrane. They consist of various molecules and form droplets with liquid-like properties that are important for stress reactions and the transmission of signals in cells.

The international research team, with researchers from Berlin, London, Beijing, Tokyo, Hong Kong and Freiberg, has now investigated how exactly these condensates interact with cell membranes. "After all, the droplets often encounter membrane-bound structures in the cells and can attach to them," says Prof Roland Knorr from HU Berlin and co-author of the study.

"The condensate settles on the membrane like a drop of water on a pane of glass. Since membranes, unlike glass, are very soft, the condensates and the membrane can deform each other. If the physical conditions are right, the droplet can be enclosed by the membrane and finally split off." Until now, it was assumed that special proteins were required for the final step in cells.

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