The facility is located in the city of Benina, some 19 kilometres outside the country’s second city, Benghazi.
Known previously as Hugo Chávez Stadium, the venue is a 10,000-capacity facility with an artificial turf.
While the match in Uyo will kick off at 5 pm, the battle in Benina will commence at 8 pm Nigerian time.
Nigeria tops the pool with four points after a 3-0 thrashing of Benin Republic in Uyo on match-day one and a goalless draw against Rwanda’s Amavubi in Kigali in their second game.
Libya, meanwhile, remains bottom of Group D after two rounds of matches, following a 1-1 draw at home to Rwanda (a game that was played at the Tripoli International Stadium) and a 2-1 loss to the Cheetahs of Benin Republic in Abidjan.