Jets quarterback Aaron Rodgers suffered a season-ending injury in the first quarter of his New York debut last year, but he will make his return to the field on Monday, Sept. 9. The Jets will visit the 49ers in the final game of the Week 1 NFL schedule, with San Francisco a four-point home favorite in the Week 1 NFL odds. The 49ers are coming off a Super Bowl loss to the Chiefs, while the Jets went 7-10 and missed the playoffs last season. Other primetime matchups for your Week 1 NFL parlay picks include Chiefs vs. Ravens, Eagles vs. Packers, and Lions vs. Rams. There are not any double-digit favorites on the NFL Vegas odds board for Week 1, and only one team is favored by at least one touchdown.

Oddsmakers are expecting close games across the league, so which teams should you back with your Week 1 NFL parlay bets? Before you make any Week 1 NFL picks or NFL parlays, be sure to see the NFL predictions and betting advice from SportsLine’s proven computer model.

The model, which simulates every NFL game 10,000 times, is up well over $7,000 for $100 players on top-rated NFL picks since its inception. The model enters Week 1 of the 2024 NFL season on an incredible 185-129 run on top-rated NFL picks that dates back to the 2017 season. It is also on a 39-21 roll on top-rated NFL picks since Week 7 of last season.

Now, the model has scoured the Week 1 NFL odds and locked in five confident NFL best bets. If you successfully parlay its picks, you’d be looking at a massive payout of around 25-1. You can only see the model’s Week 1 NFL picks at SportsLine.

Top Week 1 NFL picks

After simulating every game 10,000 times, the model is high on the Detroit Lions (-3.5) to cover at home against the Los Angeles Rams. Detroit has improved more than any team in the NFL over the last three seasons, turning into a Super Bowl contender last season. The Lions have covered the spread at a 37-17 clip since 2021, which is the best mark in the league.

They have one of the top offenses in the NFL led by quarterback Jared Goff, running back Jahmyr Gibbs and tight end Sam LaPorta. Detroit is 19-8 against the spread at home since 2021, and it has covered in seven of its last eight games in September. The Lions have won four of their last five home games against the Rams, and SportsLine’s model has them covering in well over 50% of the latest simulations for this Week 1 matchup. See which other NFL parlay picks to make here.

How to make Week 1 NFL parlays

The model also jumped on four other NFL matchups where it says the line is way off, including a home favorite that covers the spread in almost 70% of simulations. You can only see the model’s NFL Week 1 best bets and parlay at SportsLine.

What are the model’s top Week 1 NFL picks, and which other NFL matchups should you target for a strong 25-1 payout? Visit SportsLine now to see the Week 1 NFL best bets from a model on a 185-129 run on top-rated picks, and find out.

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