Week 2 features a matchup between last year's Offensive Rookie of the Year C.J. Stroud and the favorite to win the award this year, No. 1 pick Caleb Williams.

Which young star will lift his team to a win?

(All times ET)

49ers @ Vikings (+5)

Colin's pick, score prediction: Vikings +5 (49ers win, 26-23)

Colin's thoughts: "Niners are on a short week. … Christian McCaffrey is still out. Sam Darnold is playing his old team. He's faced them in practice. I think they [Vikings] put some pressure. … I think this goes down to the final sequence, the final minutes of the game."

Saints @ Cowboys (-6)

1 p.m., FOX and FOX Sports app

Colin's pick, score prediction: Cowboys -6 (Cowboys win, 30-20)

Colin's thoughts: "When Dak Prescott and Mike McCarthy are favored and playing an inferior team, they roll them. They're very comfortable as a favorite, playing downhill. The Saints were 1-5 against playoff teams last year. The Saints get their wins off lousy teams."

Jets @ Titans (+3.5)

Colin's pick, score prediction: Jets -3.5 (Jets win, 24-10)

Colin's thoughts: "The Jets offense is gonna get better every week. … And I'm not sure Tennessee has an NFL quarterback. The Jets were humiliated physically. They'll play with their hair on fire. Their defense will be fine."

Steelers @ Broncos (+2.5)

Colin's pick, score prediction: Broncos +2.5 (Broncos win, 23-20)

Colin's thoughts: "I think Sean Payton and his guys … they may not have great personnel, but they held the Seahawks to 158 passing yards and got two turnovers. I've said all offseason: I think Denver's personnel is better than you think."

Blazin’ 5: Vikings cover vs. 49ers, Jets beat Titans, Texans over Bears

Bears @ Texans (-6.5)

8:20 p.m., NBC

Colin's pick, score prediction: Texans -6.5 (Texans win 27-17)

Colin's thoughts: "I think C.J. Stroud is incredible. The kid's unbelievable. He's intentional with his running, he's one of the more accurate passers. Now they've given him Joe Mixon … they've added Stefon Diggs. And by the way, the Bears offense is a mess. I think Houston is gonna totally dominate time of possession. I think it's a mismatch, and I don't get the line."

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